Well i would like to keep it simple and short. If you are only looking for heavy and sturdy tones, just go for it. These strings have massive lower stings that would be very tough to bend at normal e tuning. But if you will drop it down to D or C, you could get the best of it. Please note if you like to bend your lower strings too much while playing, these strings are not for you. You should probably go for the 42 or 48. 52 is just to hard/heavy. High strings are smooth and easy to bend compare to low strings. If you are a metal player and generally like to play heavy riffs on drop tunings and can easily handle the thickness of the lower strings, than go for it. If your are a solo guitarist which loves to bend, squeal strings too much, these are not for you. Also if you are an amateur guitarist, you will find these too hard to play. Thanks